- To evaluate the hearing sensitivity characteristics and auditory function from the periphery to the central auditory system function in three groups of 11-12-year-old children (children living with perinatally acquired HIV [CPHIV]; children with perinatal exposure to HIV but uninfected [CPHEU]; and children without perinatal HIV exposure [CHU]) living in Cape Town, South Africa.
- To use multimodal neuroimaging techniques (structural, task based and resting state functional MRI [FMRI], and diffusion tensor imaging [DTI]) to examine the neural correlates of hearing outcomes in CPHIV, CPHEU and CHU.
- To evaluate the effects of HIV disease severity and antiretroviral therapy (ART) on clinical, subclinical, and neuroimaging hearing-specific outcome measures.
